منابع مشابه
Sirtuins, aging, and metabolism.
Sirtuins are nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases that link protein acetylation, metabolism, aging, and diseases of aging. Sirtuins were initially found to slow aging in lower organisms and more recently shown to mediate many effects of calorie restriction on metabolism and longevity in mammals. This chapter focuses on two key mammalian sirtuins, SIRT1 (which r...
متن کاملSirtuins, aging and diseases
SIR2 and related genes (sirtuins) are NAD-dependent deacetylases that link metabolism, protein acetylation and aging in a variety of species. Sirtuins are also involved in the longevity conferred by dietary or calorie restriction (CR). The mammalian sirtuins SIRT1-7 are involved in changes in stress resistance and metabolism that are triggered by CR, which not only extends life span, but also p...
متن کاملRetinal aging and sirtuins.
The process of aging involves the accumulating changes in the microenvironment that lead to cell senescence or apoptosis, and subsequent tissue or organ dysfunction. Multiple extrinsic and intrinsic events that cause DNA instability are associated with aging. Cells containing unstable DNA are biologically vulnerable, and if the DNA damage is too great for the cell to repair, it becomes senescen...
متن کاملSirtuins, Aging, and Medicine
Copyright © 2011 Massachusetts Medical Society. Populations in developed countries continue to grow older, as medical advances allow baby boomers to march inexorably onward. Many of the most important diseases that lead to disability and death occur late in life, indicating that aging itself is a key risk factor. Recent research into the science of aging has identified genes and pathways that a...
متن کاملMitochondrial metabolism, sirtuins, and aging.
The sirtuins are a family of proteins that act predominantly as nicotinamide adenine dinucleotide (NAD)-dependent deacetylases. In mammals seven sirtuin family members exist, including three members, Sirt3, Sirt4, and Sirt5, that localize exclusively within the mitochondria. Although originally linked to life-span regulation in simple organisms, this family of proteins appears to have various a...
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ژورنال
عنوان ژورنال: AGE
سال: 2015
ISSN: 0161-9152,1574-4647
DOI: 10.1007/s11357-015-9804-y